21 research outputs found
Infrastructure for Detector Research and Development towards the International Linear Collider
The EUDET-project was launched to create an infrastructure for developing and
testing new and advanced detector technologies to be used at a future linear
collider. The aim was to make possible experimentation and analysis of data for
institutes, which otherwise could not be realized due to lack of resources. The
infrastructure comprised an analysis and software network, and instrumentation
infrastructures for tracking detectors as well as for calorimetry.Comment: 54 pages, 48 picture
A Sodium Leak Current Regulates Pacemaker Activity of Adult Central Pattern Generator Neurons in Lymnaea Stagnalis
The resting membrane potential of the pacemaker neurons is one of the essential
mechanisms underlying rhythm generation. In this study, we described the
biophysical properties of an uncharacterized channel (U-type channel) and
investigated the role of the channel in the rhythmic activity of a respiratory
pacemaker neuron and the respiratory behaviour in adult freshwater snail
Lymnaea stagnalis. Our results show that the channel
conducts an inward leak current carried by Na+
(ILeak-Na). The ILeak-Na contributed to the resting
membrane potential and was required for maintaining rhythmic action potential
bursting activity of the identified pacemaker RPeD1 neurons. Partial knockdown
of the U-type channel suppressed the aerial respiratory behaviour of the adult
snail in vivo. These findings identified the
Na+ leak conductance via the U-type channel, likely a
NALCN-like channel, as one of the fundamental mechanisms regulating rhythm
activity of pacemaker neurons and respiratory behaviour in adult animals